Hyaluronidase is an enzyme used to break down and dissolve hyaluronic acid dermal fillers. It is commonly used to:
Correct lumps, migration, asymmetry, or overfilling
Treat complications such as vascular occlusion, where a filler blocks a blood vessel
Reverse undesired results from previous filler treatments, even if carried out by another practitioner
This is a prescription-only medication and must only be administered by a qualified medical professional.
Important Information
A patch test may be carried out 20 minutes prior to full treatment to assess for allergic reaction, unless treatment is urgent (e.g., vascular compromise).
Hyaluronidase is not selective — it can dissolve natural hyaluronic acid as well as injected filler and may cause volume loss in the treated area.
In some cases, more than one treatment may be required to fully dissolve the filler.
The treatment may result in the need to re-treat with filler after the area has healed (typically after 2–4 weeks).
This treatment is not suitable for correcting non-hyaluronic acid fillers.
Contraindications
You must not undergo hyaluronidase treatment if you:
Are allergic to hyaluronidase, bee stings, or bovine proteins
Have had a previous allergic or anaphylactic reaction to similar enzymes
Have an active infection, inflammation, or skin condition at the treatment site
Are pregnant or breastfeeding (unless in an emergency such as a vascular occlusion)
Risks and Side Effects
Common side effects include:
Swelling, bruising, redness, or tenderness at the injection site
Mild stinging or discomfort during injection
Temporary loss of volume or hollowing in the treated area
Less common but possible complications:
Allergic reaction or anaphylaxis — even with previous exposure
Infection (if aftercare is not followed)
Incomplete dissolving, requiring further treatment
In the event of a vascular occlusion, hyaluronidase may be used urgently, sometimes without a patch test, to prevent skin damage, tissue necrosis, or other serious complications. Your practitioner will discuss this with you.
Aftercare Instructions
Avoid touching, rubbing, or massaging the treated area for at least 6 hours.
Avoid makeup for 12–24 hours, unless advised otherwise.
Use antihistamines or cold compresses if you experience mild swelling or itching (unless instructed otherwise).
Attend any follow-up appointments as recommended.
Avoid alcohol, exercise, or excessive heat exposure for 24 hours.
Consent Declaration
By signing this form, I confirm that:
I have been fully informed about the use of hyaluronidase, including the indications, benefits, risks, and alternatives.
I have disclosed all known allergies, particularly to hyaluronidase, bee venom, or animal proteins.
I understand that hyaluronidase can dissolve both filler and natural hyaluronic acid, and volume loss may occur.
I understand that more than one session may be required.
I have had the opportunity to ask questions, and they have been answered to my satisfaction.
I understand the risks, including allergic reactions, and accept that no guarantees can be made regarding the outcome.
I agree to follow all aftercare advice given by my practitioner.
I voluntarily consent to receive hyaluronidase treatment administered by a qualified medical practitioner.
